Coxiella Burnetii: Host and Bacterial Responses to Infection

Abstract

Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. Advances in the study of this microorganism proceeded slowly, primarily because of the difficulty in studying this obligate intracellular pathogen that must be manipulated under biosafety level-3 conditions. The dogged determination of past and current C. burnetii researchers and the application of modern immunological and molecular techniques have more clearly defined the host and bacterial response to infection. This review is intended to provide a basic introduction to C. burnetii and Q fever, while emphasizing immunomodulatory properties, both positive and negative, of Q fever vaccines and C. burnetii infections.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 16, 2007
Accession Number
ADA476318

Entities

People

  • David M. Waag

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bacteriology
  • Biological Factors
  • Blood
  • Cardiovascular System
  • Cells
  • Chemistry
  • Disease Attributes
  • Infection
  • Infectious Diseases
  • Lymphocytes
  • Microbiology
  • Microorganisms
  • Peptides
  • Proteins
  • Public Health
  • Q Fever
  • Rodents

Readers

  • Educational Psychology
  • Infectious Disease/Epidemiology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology