Role of STAT5b in Breast Cancer Progression and Metastasis
Abstract
The signal transducer and activator of transcription (STAT) 5b is involved in tumorigenic signaling in a number of cancers including breast cancer. However, its importance in breast cancer metastasis has not been investigated. Thus, this research aims to determine the role of STAT5b in breast cancer migration, invasion, and metastasis. We have found that STAT5b is essential for BT-549 and MDA-MB-231 migration to serum, as evidenced by the fact that knockdown of STAT5b inhibits migration in these cell lines by 60-80%. In addition, STAT5b knockdown inhibits BT-549 invasion through Matrigel. Furthermore, while these cells migrate well to vitronectin, this migration is inhibited in the absence of STAT5b. Therefore, STAT5b is important for migration and invasion of breast cancer cells and may be involved in adhesion of these cells to vitronectin. Further elucidating the mechanism by which STAT5b promotes migration and invasion of breast cancer cells may lead to more effective treatments for preventing and treating metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2007
- Accession Number
- ADA476372
Entities
People
- Teresa Bernaciak
Organizations
- University of Virginia