Hybrid Semiconductor Nanostructures as Unique Capabilities in the Direct Detection of Proteins, Viruses, and DNA
Abstract
Nano approach to fighting cancer is exploding. Devices based on field-effect transistors (FETs) are one of emerging fields for sensing technology. Several other research terms have made similar progress in electrically detecting cancer specific markers using new types of nanodevices. Lieber and colleagues doped charge-carrying silicon nanowires with monoclonal antibodies specific for the cancer proteins. When the proteins linked up with the antibodies, the electrical charges of the proteins changed the conductance of the silicon wires. This change signaled the presence and concentration of cancer markers. Hence, the electrical signal transduction plays an important role on EFTs devices for the direct detection of biological and chemical species. In addition to silicon nanowires, today nanostructured semiconducting oxides, such as SnO2, ZnO2, and V2O5, have attracted extensive interest because of their distinctive electronic and/or optical properties. In particular, individual nanowires or nanotubes have been fabricated recently on field-effect transistor devices that provide a very promising technology for chemical and biological sensors. However, the electrical signal transduction for semiconductor oxides in general take place at high temperature (above at 200 degree C), at which temperature environment will damage biomolecules. We proposed an entirely new ideal to synthesize organic-inorganic hybrid synergistic semiconductors. We suggested that the redox organic radical molecules may be trapped into the crystalline oxide to become a new hybrid-semiconductor that is thought to enrich electronic transport through the surface of the oxides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 06, 2008
- Accession Number
- ADA476381
Entities
People
- Ching-hsiu Tsai
- Kuan-jiuh Lin
- Watson Kuo
Organizations
- National Chung Hsing University