Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer
Abstract
We have made headway into understanding the paracrine relationship between neuropeptide expressing, androgen-insensitive CaP cells and their ability to support the proliferation and migration of androgen sensitive CaP cells. Critically, we have identified src kinase as a molecule central to the process. We have been awarded a NIH CTEP phase II trial to study a novel, oral src kinase inhibitor AZD0530 in androgen-insensitive prostate cancer patients based upon our work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2007
- Accession Number
- ADA476747
Entities
People
- Christopher P Evans
Organizations
- University of California