Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression

Abstract

We have found that the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer and with metastasis and PSA recurrence in men undergoing radical prostatectomy. Our published data indicates that FGFR-4 plays an important role in prostate cancer initiation and progression. We have now proven that FGFR-4 plays an important role in prostate cancer progression in vivo. We have established that Ehm2 plays an important role in this process. Furthermore, HIP1 plays an important role in modulating FGFR-4 Gly388 activity and is associated with more aggressive prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2007
Accession Number
ADA476749

Entities

People

  • Michael M. Ittmann

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Bacterial Proteins
  • Biological Sciences
  • Cancer
  • Carcinoma
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Colon Cancer
  • Medical Personnel
  • Metastasis
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Library and Information Science/ Studies, Southeast Asia Studies, Bibliography of Vietnam and Lao Studies.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).