Polymicrobial Chronic Infection Including Acinetobacter Baumannii in a Plated Segmental Defect in the Rat Femur
Abstract
The goal of this work was to develop a model of a realistic polymicrobial infection with bony involvement in an internally stabilized segmental defect in the rat femur. This model could then be used to assess the combined therapy of an osteogenic agent to stimulate bone formation while local and system antibiotic therapy was being applied to control the polymicrobial infection. A bone isolate of Acinetobacter baumanii exhibited very little osteolytic involvement when used alone in the model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2008
- Accession Number
- ADA477104
Entities
People
- Dean T. Tsukayama
Organizations
- Hennepin Healthcare Research Institute