Multi-Scale Computational Analyses of JP-8 Fuel Droplets and Vapors in Human Respiratory Airway Models
Abstract
Using representative human nasal, oral and tracheobronchial airway models, transient 3- D as well as equivalent steady-state solutions have been obtained for the transport and deposition of spherical particles and droplets as well as vapors. It should be noted that equivalence to transient airflow and particle deposition results was achieved by employing matching Reynolds and Stokes numbers for steady-state simulations. Inhalation inlet conditions and aerosol characteristics resembled JP-8 fuel exposure scenarios in most case studies. Specifically, the following major tasks have been accomplished: (i)Airflow and transport/deposition of micron- and nano-size aerosols in representative human nasal airways; (ii) multi-component and/or impure droplet evaporation or hygroscopity; (iii) deposition differences between fuel aerosols (i.e., droplets) vs. vapors; (iv) studies of JP-8 fuel vapor transport and deposition by considering airway wall absorption; and (v) optimal drug- aerosol targeting. The 3-year-project results are documented in 17 peer-reviewed journal articles (14 published and 3 accepted or submitted) and 9 conference papers/presentations. The often quoted articles have a significant impact on toxic/therapeutic aerosol research worldwide.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 31, 2007
- Accession Number
- ADA477133
Entities
People
- Clement Kleinstreuer
Organizations
- North Carolina State University