Stimulation of Estrogen Receptor Signaling in Breast Cancer by a Novel Chaperone Synuclein Gamma

Abstract

The association between SNCG expression and the progression of steroid dependent cancers of breast and ovary promoted us to investigate the role of SNCG in regulation of ERalpha. SNCG strongly stimulated the ligand-dependent transcriptional activity of ERalpha in breast cancer cells. A notable finding relevant to this study is that SNCG acting as a chaperone for ER strongly stimulated the ligand-dependent transcriptional activity of ERalpha ligand-dependent cell growth and ligand-dependent mammary tumorigenesis. Augmentation of SNCG expression stimulated the transcriptional activity of ERalpha and ligand-dependent growth whereas compromising endogenous SNCG expression suppressed ERa signaling and ligand-dependent growth.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA477293

Entities

People

  • Y. E. Shi

Organizations

  • The Feinstein Institute for Medical Research

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Gene Expression
  • Genetic Structures
  • Growth Factors
  • Health Services
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Parkinson'S Disease
  • Peptides
  • Proteins

Fields of Study

  • Biology

Readers

  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.