An Experimental System to Evaluate LOH in Prostate Cancer

Abstract

The goal of this grant is to establish a new biological system for studying the progression of prostate cancer. We propose a technology we have previously developed to help define X-chromosome inactivation to increase our understanding of the molecular biology of prostate cancer. Using a mouse model, our goal is to induce functional Loss of Heterozygosity (LOH) on a particular chromosome at various specified time during development or life span. Specifically, we plan to induce LOH only in mouse prostatic tissue.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2004
Accession Number
ADA477389

Entities

People

  • William M. Strauss

Organizations

  • University of Colorado Boulder

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Chromosomes
  • Colorado
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Molecular Biology
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Standards
  • Systems Biology
  • Tissues

Readers

  • Molecular and genetic basis of cancer.