Integration of Diagnostic and Interventional MRI for the Study of Persistent Prostate Cancer After External Beam Radiotherapy

Abstract

This study involves the technical development and clinical testing of a novel technique for magnetic resonance imaging (MRI) guided prostate biopsy in a 1.5T horizontal bore scanner using a dedicated interventional table. We primarily hypothesize that the integration of diagnostic and interventional MRI enables needle biopsy targeting to foci of tumor recurrence after radiotherapy, and will enable a determination of the diagnostic accuracy of MRI in mapping sub-sites of tumor recurrence after radiotherapy. Major finding to date: This clinical study received ethics approval from USAMRCMC approval on October 13 2006. Funds were released after HSRRB approval, and received in September 2006. In the first year of research,14 patients have been accrued to stage 1 (phase 1) of the trial. We will proceed to Stage 2 as soon as we receive HSRRB approval of study amendment. Tasks 1a-1d are complete, as per the Statement of work.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2007
Accession Number
ADA477475

Entities

People

  • Cynthia Ménard

Organizations

  • University Health Network

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Biomedical Research
  • Coordinate Systems
  • Diagnostic Imaging
  • Displacement
  • Engineering
  • Health Services
  • Imaging Techniques
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Prostate Gland
  • Radiotherapy
  • Targeting
  • United States

Fields of Study

  • Medicine
  • Physics

Readers

  • Clinical Trial Research.
  • Medical Imaging.