MRI Study of Uninvolved Breast Tissue for Patients With Locally Advanced Breast Cancer Undergoing Pre-Operative Chemotherapy
Abstract
Purpose: To study possible associations between the MRI morphological patterns of the primary breast tumor and properties of the surrounding host tissue. Scope: Identification of such properties of host tissue may be useful in characterizing breast tissue for earlier stage breast cancers. Major findings: We have developed MRI algorithms necessary to measure signal enhancement ratios in non-tumor tissue using the existing database of patients who underwent neoadjuvant chemotherapy. Results: We found that change in uninvolved breast tissue volume with treatment was correlated with tumor phenotypes and was shown to be predictive of recurrence. Significance: Host tissue changes with treatment can potentially provide information about pre-cancerous tissue that may have applicability to risk assessment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2006
- Accession Number
- ADA477540
Entities
People
- Catherine Klifa
Organizations
- University of California, San Francisco