Microtubule-Associated Protein Expression and Predicting Taxane Response

Abstract

We hypothesized that in addition to its predictive value, the microtubule-associated marker tau (MAP-tau) may also function as a prognostic biomarker. The dual functionality of MAP-tau may translate into increased tumor molecular screening information for patients with breast cancer resulting in better treatment options. The results of this work indicate that MAP-tau functions as a prognostic marker for paclitaxel sensitivity when examined using automated quantitative analysis (AQUA) and tissue arrays YTMA 49-5 and YTMA 49-6. Each array contained approximately 750 tumor histospots. This work demonstrates that MAPtau may be useful for further differentiating ER (+) and ER (-) patients and that increased MAP-tau expression in newly diagnosed breast cancer patients is associated with better outcome. Our findings suggest that MAP-tau may be a useful prognostic marker in addition to its predictive value for taxane response.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2007
Accession Number
ADA477584

Entities

People

  • Maria T. Baquero

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Algorithms
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Cellular Structures
  • Cytoplasm
  • Cytoskeleton
  • Data Analysis
  • Lymph Nodes
  • Medical Personnel
  • Neoplasms
  • Quality Of Life
  • Sensitivity
  • Statistical Analysis

Readers

  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.