Identification and Characterization of an X-Linked Familial Prostate Cancer Gene
Abstract
Prostate cancer is the most commonly diagnosed non-skin malignancy in males, with as many as one in 5 males living in developed nations being diagnosed with prostate cancer in their lifetime. Despite the medical significance of prostate cancer our understanding of predisposition and progression in the disease remains rudimentary. Prostate cancer is estimated to have the largest heritable component of all common cancers. We will explicitly characterize ancestral versions of a gene region originally implicated in prostate cancer through study of families with multiple cases of prostate cancer (HPC) to enable us to test the hypothesis that a common disease-predisposing genetic mutation conferring modest risk is shared among present-day prostate cancer cases in the broader population by virture of inheritance from an ancient founder. We hope the findings of this proposal will offer a promising inroad for predicting disease predisposition, for tailoring the most effective current therapy to each individual patient, and for developing rational new therapies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2007
- Accession Number
- ADA477644
Entities
People
- Brian Yaspan
Organizations
- Vanderbilt University Medical Center