Nf-Kappab as a Critical Biological Link Between Psychological Stress and Breast Cancer
Abstract
It is a widespread belief that psychological stress is a major factor in breast cancer. However, the biological pathways that link stress to increased breast cancer risk are not well understood. The nuclear factor-kappaB (NF-kB) family of transcription factors is recognized as linking inflammation and immunity to cancer. NF-kB signaling is positioned as a pivotal regulator of aberrant responses that lead to cancer. We tested the hypothesis that NF-kB is a critical biological link between psychological stress and breast cancer. We made innovative use of reporter transgenic mice to measure NF-kB responses to acute and chronic stress and subsequent effects on breast cancer progression. Our data suggest that NF-kB activity is changed in response to both acute and chronic stress and that this impacts both primary tumor formation and subsequent metastasis to the lung.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2007
- Accession Number
- ADA477945
Entities
People
- Fiona E. Yull
Organizations
- Vanderbilt University