Preclinical Mouse Models of Neurofibromatosis
Abstract
This report describes the seventh year of research, and the second under this award, by a Consortium of investigators who have been continuously funded by this Program to develop, characterize, and utilize strains of mice that accurately model tumors found in persons with NF1 and NF2. This Consortium has generated many novel models of NF1 and NF2-associated tumors and has exploited these strains to investigate biologic and preclinical questions. These strains are a cornerstone of a recent initiative by the Children's Tumor Foundation to organize and support a preclinical network for testing therapeutics that might benefit persons with NF1 and NF2 disease. The investigators collaborate closely and share expertise and reagents extensively. This NF Consortium is a member of the Mouse Models of Human Cancer Consortium of the National Cancer Institute and is participating fully in the activities of the group.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2007
- Accession Number
- ADA478416
Entities
People
- Kevin Shannon
Organizations
- University of California, San Francisco