Modulation of TRAIL Cytotoxicity by Amiloride in Prostate Cancer

Abstract

The challenge today is to develop a cytotoxic agent that selectively induces cytotoxicity in prostate cancer cells but avoids significant toxicity to the normal tissues. In this study, we will develop a novel strategy by using TRAIL in combination with amiloride.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA478465

Entities

People

  • Ki Mo Kim
  • Young-ho Kim

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Androgen Receptors
  • Apoptosis
  • Biological Factors
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Cytotoxins
  • Free Radicals
  • Gene Expression
  • Inhibition
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Toxicity
  • Transcription Factors

Readers

  • Military Science
  • Molecular Genetics
  • Oncology