Small Molecule Activation of Procaspase-2 for the Selective Induction of Apoptotic Death in Breast Cancer Cells

Abstract

We have synthesized a library of compounds based on a previously identified procaspase-2 activator. These compounds were then tested for their ability to activate procaspase-2 in vitro. The results from these tests indicated that several of the compounds did indeed activate procaspase-2. Testing of these active compounds against a panel of enzymes then revealed, surprisingly, that the compounds are general enzyme activators. We have now explored this phenomena of general enzyme activation more thoroughly and have submitted a manuscript on the topic. The data and knowledge acquired through this work now allows us to move confidently to a high-throughput screen to identify truly specific procaspase-2 activators.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2007
Accession Number
ADA478661

Entities

People

  • Paul J. Hergenrother

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Aromatic Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Enzyme Activators
  • Molecules
  • Neoplasms
  • Neutral Amino Acids
  • Small Molecules
  • Throughput

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology and Biomarker-Based Cancer Detection.
  • Systems Analysis and Design