Contribution of AMACR and Phytanic Acid to Prostate Cancer Risk Among African Americans in North Carolina
Abstract
Several lines of evidence have suggested genetic and dietary differences may be important in PCa particularly among AA (African American) men. In this study we aim to test the hypothesis that mutations/sequence variants in the AMACR gene and dietary intake of foods rich in phytanic acid increase the risk to PCa among AA men. We will conduct a population based study by ascertaining 250 AA men who have PCa and 250 race age and county-matched controls from eight counties of North Carolina. We are in the process of carrying out the 1st task study subject recruitment through the year 2008. In the past funding year we have expanded our study area and significantly increased our rate of subject recruitment. Additionally we have also obtained additional grant funding related to the science of this project which will help provide independent confirmation of the findings from this study in a different study population. The results from this study as well as other future studies based on this study population will greatly increase our knowledge for potential risk factors and suggest potential preventive strategies for prostate cancer in AA men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 14, 2008
- Accession Number
- ADA479339
Entities
People
- Bao-li Chang
Organizations
- Wake Forest University