Androgen, Estrogen, and the Bone Marrow Microenvironment

Abstract

In this project we plan to analyze androgen- and estrogen-responsive gene expression in the bone marrow. We plan to work to: determine if castration-induced gene expression changes in mouse bone marrow are caused by the deficiency of testosterone or estrogen; analyze androgen- and estrogen-sensitive cytokine and gene expression changes in human bone marrow transplanted into NOD/SCID mice and; examine androgen- and estrogen-sensitive gene expression in the bone marrow of patients with low and high circulating testosterone levels. Preliminary results show that with the androgen metabolizing genes examined in the bone marrow samples from patients with prostate cancer there is little evidence for a positive correlation between androgen (testosterone) and androgen metabolizing gene expression levels.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2007
Accession Number
ADA479729

Entities

People

  • Beatrice S Knudsen

Organizations

  • Fred Hutchinson Cancer Center

Tags

DTIC Thesaurus Topics

  • Androgens
  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cancer
  • Castration
  • Cells
  • Cytokines
  • Deficiencies
  • Diseases And Disorders
  • Estrogens
  • Gene Expression
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Surgery
  • Testosterone

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology and Biomarker-Based Cancer Detection.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology