Fresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion

Abstract

Acidosis, hypothermia, and coagulopathy ,were identified more than 20 years ago as a deadly triad for patients presenting with exsanguinating hemorrhage. This led to fundamental changes in initial management of severely injured patients. Despite major advances, hemorrhage remains a leading cause of early death in trauma patients. Recent studies report most severely injured patients to be coagulopathic at admission, before resuscitation interventions, and that traditional massive transfusion practice grossly underestimates needs. The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA480289

Entities

People

  • Bjorn C. Balldin
  • Bruce A. Mckinley
  • Charles C. Miller
  • Christine S. Cocanour
  • Ernest A. Gonzalez
  • Frederick A. Moore
  • John B Holcomb
  • Rosemary A. Kozar
  • S. R. Todd

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Banks
  • Blood Transfusions
  • Bone Fractures
  • Cardiovascular Physiological Phenomena
  • Catheters
  • Databases
  • Health Services
  • Hemorrhage
  • Hospitals
  • Intensive Care Units
  • Medical Personnel
  • Patient Care
  • Risk Factors
  • Therapy

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.
  • Trauma or Military Medicine