Applications of Environmental Cell - Transmission Electron Microscopy for the Microcharacterization of Bio-alteration Products and the Study of Bio-processes
Abstract
Environmental Cell (EC)- Transmission Electron Microscopy (TEM) is a powerful technique in which hydrated specimens (at tens of torr pressure) can be examined at high spatial resolution in more or less their natural state. Two methods have been used in environmental TEM instruments: closed-cell specimen holders (e.g., see Fig. 1) and open-cell differential column pumping. Several applications of closed-cell EC-TEM are discussed in which chemical and high-resolution structural information were obtained on hydrated, microbial alteration products. Also discussed is the profound application of closed-cell EC-TEM for the in-situ study of functioning biomolecules.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2004
- Accession Number
- ADA480558
Entities
People
- Tyrone L. Daulton
Organizations
- United States Naval Research Laboratory