A Double-Blind, Placebo Controlled Study to Evaluate the Safety and Immunogenicity of the New, Live, Oral Type-4 and Type-7 Adenovirus Vaccines in Military Trainees
Abstract
Adenoviruses have been an important cause of febrile acute respiratory disease(ARD) in military recruits since they were first implicated as a cause of ARD in 1953 in an epidemic at Fort Leonard Wood, MO. Since then, adenovirus type 4 and 7 have been the most important cause of ARD among military recruits in the United States, resulting in significant morbidity, loss of training time, and in rare instances, mortality. Prior to the introduction of live, oral adenovirus vaccines in 1971, adenoviral infections caused the hospitalizations of 10% of military recruits, 90% of pneumonia hospitalizations, and more than 67% of all respiratory diseases in basic training. Outbreaks in the civilian population, though rare, have occurred.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 27, 2006
- Accession Number
- ADA481049
Entities
People
- Arthur Lyons
- David Craft
- Irma B. Froh
- Jenice Longfield
- Jitvimol Seriwatana
- Kevin Mcnabb
- Leonard Binn
- Raven Reitstetter
- Robert Kuschner
- Timothy Straight
Organizations
- Walter Reed Army Institute of Research