Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors

Abstract

This study describes the synthesis, characterization and in vitro evaluation of N-(2-hydroxypropyl) methacrylamide(HPMA) copolymer-gadolinium(Gd)-doxorubicin (Dox) conjugates. Copolymers of HPMA were derivatized to incorporate side chains for Gd chelation and Dox conjugation. The conjugates were characterized by their side chain contents T1 relaxivity (r1) stability, and in vitro cytotoxicity. High stability and relaxivity of these conjugates coupled with low toxicity show their potential for monitoring the in vivo fate of HPMA-based drug delivery systems by magnetic resonance imaging techniques.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2007
Accession Number
ADA481180

Entities

People

  • Bahar Zarabi

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Department Of Defense
  • Drug Therapy
  • Electronic Mail
  • Imaging Techniques
  • Information Operations
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Maryland
  • Neoplasms
  • Resonance

Fields of Study

  • Chemistry
  • Materials science

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).
  • Polymer Science and Technology

Technology Areas

  • Microelectronics