A Controlled Trial of Chemoprevention Using COX-2 Inhibitors in an Avian Model of Spontaneous Ovarian Carcinogesis
Abstract
The objective of this study was to determine in a controlled chemoprevention trial the ability of a COX-2 inhibitor to inhibit the development of spontaneously arising genital tract adenocarcinoma in the laying hen (Gall us Domesticus) animal model of ovarian cancer. Following a dose finding study for the COX-2 inhibitor Rimadyl 480 hens were utilized in a controlled trial of this agent to determine the subsequent development of genital tract adenocarcinoma by histologic examination. Assessment of egg count data suggests no reduction in the number of eggs produced in the animals treated exposed to COX-2 inhibitor. There was no evidence of a reduction of reproductive tract adenocarcinoma. In this study no reduction in the incidence of genital tract adenocarcinoma was observed in the laying hen model following exposure to a COX-2 inhibitor. It is of significant interest that no effect on ovulatory activity was observed. This study potentially helps shed light on the importance of reducing ovulatory activity in the pursuit of ideal chemopreventive agents for ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2007
- Accession Number
- ADA481405
Entities
People
- Mack N. Barnes
Organizations
- University of Alabama