The Role of Energy Metabolism in Cutaneous Sulfur Mustard Injury

Abstract

Over the past 17 years, our research efforts have focused on systematic studies of the effects of sulfur mustard (2,2'-dichlorodiethyl sulfide, HD) on energy metabolism in human epidermal keratinocytes (KEK). Our objectives are to define mechanisms of HD-induced metabolic injury, determine their role in the cutaneous pathology observed and provide mechanistic information that can be used in development of vesicant agent medical countermeasures. We have characterized effects of HD on the major pathways of cellular energy metabolism in HEK. Our research has shown that inhibition of energy metabolism and depletion of energy stores are a significant consequence of HD exposure and that this inhibition is severe enough to be a determining factor in both cell survival and repair of HD-induced damage. In this paper we present an overview of our results and conclusions to date and briefly discuss their implications.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA481432

Entities

People

  • M. E. Martens

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Apoptosis
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Countermeasures
  • Epithelial Cells
  • Inhibition
  • Intracellular Membranes
  • Medical Countermeasures
  • Membrane Potentials
  • Metabolism
  • Vesicants

Fields of Study

  • Medicine

Readers

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  • Systems Analysis and Design