Genotyping of Global Yersinia Pestis Isolates by Using IS285

Abstract

Yersinia pestis is the etiologic agent of bubonic and pneumonic plague, one of the most dangerous bacterial infections. Plague is a re-emerging disease displaying current tendency to increasing reports of human cases, including the affliction with multidrug-resistant strains of Y. pestis. The plague bacterium is a potential agent of biowarfare and bioterrorism. Therefore, both military and civilian specialists should have efficient methods of molecular identification of Y. pestis strains and their assignment to certain ecological variants. In this work, we consider literature data, as well as our previous and new results on genotyping of global Y. pestis strains. We come to conclusion that a mobile genetic element, IS285, is one of the most powerful molecular tools allowing to trace the circulation of epidemic clones and to detect their geographical/animal origin.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA481533

Entities

People

  • A. A. Filippov
  • A. G. Bobrov
  • Eloy García
  • L. E. Lindler
  • X.-z. Huang

Organizations

  • University of Kentucky

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Asia
  • Bacterial Infections
  • Central Asia
  • Diseases And Disorders
  • Epidemiology
  • Genetic Structures
  • Genetics
  • Genome
  • Identification
  • Infectious Diseases
  • Microbiology
  • Public Health
  • Rodents
  • United States
  • Ussr

Fields of Study

  • Biology

Readers

  • Infectious Disease/Epidemiology
  • Microbial Pathology
  • Systems Analysis and Design

Technology Areas

  • Biotechnology