Evaluation of Decontamination Systems Challenged With Nerve Agents

Abstract

Current doctrine describes the use of the M291 Skin Decontamination Kit (SDK), 0.5% hypochlorite solution (household bleach diluted 1 to 10) and 1% soapy water solution to decontaminate skin exposed to chemical warfare agents. Reactive Skin Decontamination Lotion (RSDL) is a new product being considered and was recently approved by the FDA. This study directly compares the efficacy of these four decontamination products, in the clipped haired guinea pig model, following challenges by soman (GD), VX, and Russian VX (VR). The protective ratio (PR) was calculated from the derived median lethal dose-response curves established for each agent and non-decontaminated control animals. RSDL was found to be the most effective decontamination system, whereas the M291 SDK was the least effective.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA481542

Entities

People

  • B. F. Doxzon
  • E. Clarkson
  • E. H. Braue Jr.
  • H. L. Lumpkin
  • K. A. Hanssen

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Decontamination
  • Decontamination Kits
  • Ethers
  • Families (Human)
  • Kits
  • Lethal Dosage
  • Materials
  • Nerve Agents
  • Resins
  • Rodents
  • Weapons

Fields of Study

  • Medicine

Readers

  • Environmental Engineering.
  • Neurotoxicology
  • Toxicology/Environmental Toxicology