Identification of Novel Inverted Terminal Repeat (ITR) Deletions of Human Adenovirus (AD) From Infected Host: Virulent Ads Containing Mixed Populations of Genomic Sequences
Abstract
There are a total six different species of human Adenoviruses, designated A through F. All Ads implicated in US military ARD infections are confined within two Ad species, B and E. It was demonstrated and confirmed that the clinical human Ad isolates from natural infections examined in this study carrying random terminal ITR deletions. Whereas, laboratory adapted human Ads including Ad human vaccine strains, such as Wyeth Ad4 and Ad7 strains contain mostly homogeneous and intact ITR sequences. The finding of novel ITR deletions in clinical Ads of natural infections could have significant impacts on the future Ad research and vaccine development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2006
- Accession Number
- ADA481581
Entities
People
- David Metzgar
- Huo-shu H. Houng
- Julia Lynch
- Kevin Russell
- Leonard Binn
- Robert Kuschner
Organizations
- Walter Reed Army Institute of Research