Role of Caveolin-1 in Prostate Cancer Angiogenesis

Abstract

My laboratory relocated to M. D. Anderson Cancer Center on October 1, 2008. The move and transition was handled in a very efficient manner and we did not compromise our progress toward the goals of this project in any way. With only slight modifications Tasks 1-3 are on schedule and we are progressing toward our stated goals. Notable achievements for the past year of funding include comprehensive documentation that prostate cancer cell derived, secreted caveolin-1 is taken up by cancer cells and tumor associated endothelial cells (Tahir et al., Cancer Res 68: 731-739, 2008). This autocrine/paracrine activity of secreted caveolin-1 promotes malignant progression and provides an accessible therapeutic target. In pursuit of a clinical therapy based on this mechanism we have also shown that systemic delivery of caveolin-1 antiserum suppresses primary tumor growth and increases survival in an immunocompetent mouse model of prostate cancer (see Fig 5-7). In our view these results represent a paradigm shift in prostate cancer translational research.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2007
Accession Number
ADA481662

Entities

People

  • Timothy C Thompson

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Blood Coagulation Factors
  • Carcinoma
  • Cell Membrane
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Endothelial Cells
  • Growth Factors
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Oncology (Cancer Research).