Cellular Models for Environmental Toxicant Biomarker Discovery
Abstract
A research and development priority in the area of occupational environmental health surveillance (OEHS) is the development of biomarkers of exposure, effect, and susceptibility. As exposure monitoring using environmental sampling equipment can be impractical and doesn't account for differences in individual responses, new methodologies must be sought. Biomarkers offer the opportunity to quantify toxic exposures and effects in individuals before, during, and after deployments. Therefore, concerted efforts in this area of research are underway at the U.S. Army Center for Environmental Health Research (USACEHR). This report demonstrates the feasibility of using in vitro cellular models as biomarker discovery tools. The combination of these models with state of the art proteomic screening technologies and an enzyme-linked immunosorbent assay (ELISA), provides insight into the effects of trinitrotoluene (TNT), dinitrobenzene (DNB), and the carbamate aldicarb. The results of these toxicant exposures are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2006
- Accession Number
- ADA481859
Entities
People
- David A. Jackson
- John A. Lewsis
- Kelly M. Halverson
- Linda Brennan
- Teresa Krakaner
- W. M. Dennis
Organizations
- U.S. Army Center for Environmental Health Research