Role of Obesity in Prostate Cancer Development
Abstract
Prospective epidemiological studies indicate that obesity increases the risk for prostate cancer. Also, mortality from prostate cancer is increased with elevated body weights and obesity recently was reported to be associated with higher prostate cancer grade at diagnosis and with higher recurrence rates. However, it is difficult in human studies to adequately assess effects of body weight or the effect of body weight change at specific ages on prostate cancer. Here we used the TRAMP mouse model of prostate cancer and induced obesity by injections of gold-thioglucose (GTG) at either 6, 16 or 26 weeks of age. Mice were followed until 46 weeks of age. Overall GTG led to a high death rate and obesity did not appear to negatively impact prostate cancer development or metastases. Tissue and serum analyses are now underway to evaluate adiponectin and leptin pathways. Additionally, we have initiated a study using mice with diet-induced obesity to assess the effect of body weight on tumor progression from TRAMP-C2 cells which were derived from a TRAMP prostate tumor. Presently tumor growth is being monitored.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA481862
Entities
People
- Margot P. Cleary
Organizations
- University of Minnesota