A Chemoprevention Trial to Study the Effects of High Tea Consumption on Smoking-Related Oxidative Stress
Abstract
Our overall goal is to develop a safe and feasible model for the chemoprevention of a wide range of tobacco-related diseases. Our immediate goal that is addressed over a 5-year study period is to determine the effects of high tea consumption on biological markers of oxidative stress that mediate lung cancer risk. We are conducting a 6-month randomized controlled double-blinded chemopreventive trial in a group of COPD subjects who are being randomized to green or black tea preparations or a control intervention (matching placebo). Levels of 8-hydroxydeoxyguanosine and 8-F2-isoprostanes are used to measure DNA and lipid damage respectively. Changes in biomarkers of oxidative damage are being measured in urine blood and exhaled breath condensate. The study protocol was approved by all parties in September 2003. Recruitment and screening of participants for eligibility criteria started in October 2003. Total recruitment was completed in December 2007. A total of 154 participants completed the study. Laboratory analyses (urine blood and sputum) for the last cohort of participants is ongoing along with data entry. We expect to complete all the laboratory analyses by June 2008 and the data analyses and final report and manuscript preparation will be completed by December 2008.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2008
- Accession Number
- ADA482127
Entities
People
- Iman A. Hakim
Organizations
- University of Arizona