Non-Invasive Markers of Tumor Growth, Metastases, and Sensitivity to Anti- Neoplastic Therapy

Abstract

The goals of this application are to develop methods to non-invasively differentiate fast and slow growing prostate tumors and also develop methods to evaluate response to anti-angiogenic agents. Validation of the results will be based on tumor growth metastases and microvessel density measurement (antiangiogenic studies). To date we have succeeded in demonstrating that the R3327AT rat prostate tumor which is relatively radiation resistant has detectable lactate which is heterogeneously distributed once the tumor exceeds 6OOmm3. In contrast the radiation sensitive slow growing Dunning H does not have lactate that is detectable by NMR. DCE-MRI studies do not suggest differences between slow and fast growing rat prostate tumors.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2008
Accession Number
ADA482242

Entities

People

  • Jason A Koutcher

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Blood
  • Chemical Shifts
  • Contrast
  • Detection
  • Frequency
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Measurement
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Radiation
  • Resonance
  • Sensitivity
  • Simulations
  • Two Dimensional

Fields of Study

  • Medicine
  • Physics

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).