Detecting Natural Versus Unnatural DNA

Abstract

We have developed computational pipeline that compares a target genome with related genomes and find regions that have been potentially engineered. Our pipeline compares the target genome with related genomes and finds "unique" genes that have no homologs. These "unique genes" can then be tested for other criteria like DNA composition to narrow down the list of potential engineered genes.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2007
Accession Number
ADA482341

Entities

People

  • Carla Brodley
  • Donna Slonim
  • Jonathan A. Eisen
  • Lenore Cowen

Organizations

  • Tufts University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Anomaly Detection
  • Bacteria
  • Bacteriology
  • Change Detection
  • Classification
  • Contracts
  • Data Sets
  • Information Science
  • Microbiology
  • Microorganisms
  • Pathogenic Bacteria
  • Prokaryotes
  • Proteobacteria
  • Supervised Machine Learning
  • Training

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Molecular Genetics