Interaction of A1B1 and BRCA1 in the Development of Breast Cancer

Abstract

AIB1 (SRC3) belongs to the p160 family of steroid receptor coactivators including SRC-1 and SRC-2. AIB1 interacts with several nuclear receptors including estrogen and progesterone receptors in a ligand-dependent manner and enhances their transcriptional activity. AIB1 is amplified and/or overexpressed in approximately 30% of breast cancers and can increase the sensitivity of breast cancer cells to estrogen and to growth factor signaling. BRCA1 regulates cell cycle progression apoptosis induction transcription and DNA repair. From 5-10% of total breast cancers are due to germ-line BRCA1 mutations that lead to a deficiency in the BRCA1 protein. We have observed that AIB1 can partially reverse BRCA1 mediated repression of ER-dependent transcriptional activity in breast cancer. This research will identify if there is a functional consequence of an interaction between AIB1 and BRCA1 in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2008
Accession Number
ADA482520

Entities

People

  • John T. Lahusen

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chromosomes
  • Culture Media
  • Estrogens
  • Genetics
  • Growth Factors
  • Hormones
  • Neoplasms
  • Progesterone
  • Proteins
  • Tumor Cell Line
  • Tyrosine

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology