Hibernation Strategies to Improve Recovery from Hemorrhagic Shock
Abstract
The ultimate goal of this project is to protect the warfighter from pathology that occurs as a result of significant blood loss. The overall strategy is to develop an effective fast-acting hemorrhagic shock protection fluid based on the molecular mechanisms used by hibernating mammals to survive reduced blood flow and avoid the consequences of ischemia and reperfusion injury. The primary deliverable derived from this Phase 1 project is the ability to protect a non-hibernating mammal against injury from hemorrhagic shock. We have already shown in preliminary experiments that ischemic rat livers are protected from damage in vivo by administration of a preconditioning solution based on a molecular profile seen in hibernators. Optimization of a hemorrhagic shock protection fluid in non-hibernating rats, and assaying for their ability to protect against hemorrhagic shock, will serve as a prelude to Phase 2 of the Surviving Blood Loss Program. The ultimate goal of our work is to protect the warfighter from pathology that occurs as a result of significant blood loss. This effort will concentrate on the preconditioning protection of two organs that are critical for successful recovery from hemorrhagic shock, the heart and brain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2007
- Accession Number
- ADA482609
Entities
People
- Lester R Drewes
- Matthew T Andrews
Organizations
- University of Minnesota Duluth