Mammary Gland Tumor Development in Transgenic Mice Overexpressing Different Isoforms of the CDP/Cux Transcription Factor
Abstract
Short CUX1 isoforms were found to be overexpressed in breast cancer cell lines, in human breast tumors and in uterine leiomyomas, suggesting that these proteins play a key role in tumor development and progression. My project consists in analyzing the effect of these CUX1 isoforms on mammary gland development and tumorigenesis. Also, I will work on the identification of targets of CUX1 that mediate its oncogenic properties. So far, I have shown that overexpressing short CUX1 isoforms leads to abnormal development of the mammary gland. Furthermore, overexpressing p75, p110 or p200 CUX1 leads to the development of mammary gland tumors in mice. These tumors seem to be of basal origin, suggesting that CUX1 promotes tumorigenesis in a precursor cell. Breast tumor patients with similar types of disease have very low chances of survival, since no specific treatment is currently available for them. Thus, my research project will enable us to gain a better understanding of the biological functions of each CUX1 isoform in mammary gland development and tumorigenesis, which could possibly lead to new therapeutic targets for the treatment of basal breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA482619
Entities
People
- Chantal Cadieux
Organizations
- McGill University