Cells with Unique Properties in Prostate Cancer-Associated Stroma are Mesenchvmal Stem Cells

Abstract

The importance of tumor stroma in prostate cancer development and progression has been recognized through its stimulating effects on cancer cell growth, migration and angiogenesis. Our hypothesis was that the prostate cancer stroma is derived, at least in part, from mesenchymal stem cells (MSCs) that are proliferative, multipotent and self-renewing. Our objective was to demonstrate that cancer-derived stromal cells have characteristics of mesenchymal stem cells. Comparing primary cultures of stromal cells from cancer versus normal tissues, we observed (a) differential gene expression profiles, (b) increased expression of autotaxin, a motility factor, (c) increased expression of the MSC-associated antigen CD90, and (d) increased expression of transforming growth factor-beta, associated with tumor promotion, in CD90-positive cells. Many of these properties are consistent with a mesenchymal stem cell phenotype of prostate cancer-associated stroma, supporting our hypothesis.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2007
Accession Number
ADA482659

Entities

People

  • Donna M. Peehl

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biological Factors
  • Cancer
  • Cells
  • Epithelial Cells
  • Gene Expression
  • Growth Factors
  • Muscle Cells
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Prostate
  • Prostate Cancer
  • Proteins
  • Stem Cells
  • Stromal Cells
  • Tissues

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology