CBP and p27KIP1 in Prostate Carcinogenesis

Abstract

CBP and p27KIP1 are two genes that are highly relevant to human prostate cancer. The objective of this proposal is to test the hypothesis that deletion of both alleles of CBP, in conjunction with deletion of one allele of p27KIP1, will result in the development of high-grade tumor in the prostate. The specific aims are to create CBP/p27KIP1 double knockout mice, to determine whether they present enhanced tumor progression compared to CBP single knockout mice alone, and to determine whether the application of two drugs, bortezomib and suberoylanilide hydroxamic acid (SAHA), are effective for the treatment of prostate tumors developed in CBP/p27KIP1 mice. As scheduled in our proposal, we have generated CBP/p27KIP1 compound knockout mice in the past funding year. Moreover, more than 120 additional mice, including CBP/p27KIP1 double knockout male mice and their control littermates, are currently maintained in our laboratory in order to monitor tumor formation and progression.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA482779

Entities

People

  • Haojie Hunag

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Amplification
  • Anatomy
  • Androgen Receptors
  • Biological Sciences
  • Biomedical Research
  • Carrier Proteins
  • Chemical Compounds
  • Chemistry
  • Diseases And Disorders
  • Genes
  • Genotypes
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Schematic Diagrams
  • Tissues

Fields of Study

  • Biology

Readers

  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Molecular and Cellular Biology
  • Oncology (Cancer Research).