Analysis of Morphogenic Effect of hDAB21P on Prostate Cancer and Its Disease Correlation

Abstract

DAB2IP was identified to be a DOC-2/DAB2 interactive protein from normal basal cell population of prostate. DAB2IP is a new member of RAS-GAP family that is known to modulate extracellular signal-elicited RAS pathways. In androgen-independent prostate cancer (AIPCa), RAS activation is often detected while DAB2IP is down regulated due to epigenetic control such as DNA methylation and histone acetylation or methylation. Genetic variation of DAB2IP is associated with the risk of aggressive PCa. In DAB2IP-knock out mouse, prostate hyperplasia is also noticed. Biochemical studies demonstrate that DAB2IP has a similar function as PTEN to modulate cell survival and apoptosis by interacting with critical proteins involved in these pathways. Thus, DAB2IP is a homeostatic complex controlling cell growth, differentiation and survival of prostate epithelia.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA482783

Entities

People

  • Jer-Tsong Hsieh

Organizations

  • University of Texas at Dallas

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Androgens
  • Apoptosis
  • Cancer
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Epithelium
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech