Radiation-Induced Immune Modulation in Prostate Cancer

Abstract

Radiotherapy is generally considered to be immunosuppressive, whereas we hypothesized that it modulates immune responses and has profound effects on the immune system rather than eliminating of lymphocytes. The goal of this study was to determine how radiation affects the presentation of prostate specific antigen (PSA), to investigate new potential mechanisms of altered immune function after radiation therapy, and to devise strategies to overcome radiation-induced immunosuppression in prostate cancer using treatment with IL-3 and/or GM-CSF. In addition, because of the high risk nature of the experiments and the high PSA expression levels in prostate cancer patients that might interfere with its efficacy, we developed a second model using survivin as an antigen, since it also is over-expressed in prostate and other cancers.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2008
Accession Number
ADA482784

Entities

People

  • William H. Mcbride

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Blood
  • Cells
  • Genetics
  • Health Services
  • Immune System
  • Ionizing Radiation
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Radiation Effects
  • Therapy

Fields of Study

  • Medicine
  • Physics

Readers

  • Immunology
  • Oncology (Cancer Research).