The Role of SnoN and Ski in Mammary Epithelial Cell Transformation

Abstract

Ski and SnoN are members of Ski oncoprotein family. Overexpression of Ski or SnoN can induce transformation of chicken embryonic fibroblast. Ski/SnoN is recently identified as a repressor of TGF signaling pathway which is an important tumor suppression pathway at the early stage of tumorigenesis. Higher level of Ski/SnoN is found in transformed mammary epithelial cells. Ski/SnoN might play a role in regulation of the transformation of mammary epithelial cell by antagonizing TGF signaling pathway. In my project, I try to explore the role of Ski/SnoN in the transformation of mammary epithelial cells.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2007
Accession Number
ADA482792

Entities

People

  • Deng Pan

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biological Aging
  • Biological Sciences
  • Biological Staining And Labeling
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Epithelial Cells
  • Fibroblasts
  • Genes
  • Infection
  • Knocking
  • Peptide Growth Factors
  • Proteins
  • Regulations
  • Wound Infections

Readers

  • Molecular Biology and Genetics
  • Nuclear Civil Defense.