Study of Detection Limits and Quantitation Accuracy Using 300 Mhz NMR
Abstract
The analytical precision and accuracy of 300 MHz nuclear magnetic resonance (NMR) spectrometers was determined. The instruments that were used include a Bruker AC-300, a Bruker Avance 300, and a Varian 300. The minimum detection limits for proton (H1) and phosphorus (P31) were determined and compared for different instruments. The Minimum Detection Limits (MDL) for proton measurements were in the range of 3-10 microg/g. The MDL for phosphorus measurements were in the range of 50-70 microg/g. The quantitation accuracy for purity determinations was measured to be in the range of 1% relative to an internal standard. Specific MDL values should be determined for each particular matrix, internal standard, and instrument conditions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA482893
Entities
People
- David J. Mcgarvey
- H. D. Durst
- Jeffrey S. Rice
- Richard O'connor
- William R. Creasy