Investigating the Role of TBX2 in the Inhibition of Senescence in Prostate Cancer

Abstract

The aim of this project is to dissect the role of Tbx2 in prostate cancer progression. In the present study we have found that by reducing the expression of Tbx2 in prostate cancer cell lines reduces proliferation in vitro. Further, utilizing tissue recombination techniques we found that the grafts obtained from NeoTag-2 mouse prostate cancer cells containing the dominant negative Tbx2 construct are more differentiated as compared to controls. These findings suggest that inducing senescence by down-regulating Tbx2 may reduce tumorigenesis and hence Tbx2 plays an important role in prostate cancer progression.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2008
Accession Number
ADA482959

Entities

People

  • Srinivas Nandana

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Adenocarcinoma
  • Androgen Receptors
  • Androgens
  • Biological Aging
  • Biomedical Research
  • Bone And Bones
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemotherapeutic Agents
  • Department Of Defense
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Retinoic Acids
  • Tissues

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).