Characterization of MHC-Related Volatile Organic Compounds in Heterologous Expression Systems: Role of Infection in Odor Compound Generation

Abstract

Major histocompatibility complex (MHC) human leukocyte antigen (HLA) in humans plays significant role in mate selection and kin recognition mainly through apparition of organism specific odor recognized by other individuals. However a mechanism of the relationship between unique MHC genetic combination of an organism and generation of the specific organism odor is not understood. We are showing here that human B cells produce volatile organic (odor) compounds measurable by GC/MS technique. More importantly, our results evidence that a presence of specific HLA allele in the cells is related to apparition of specific cell odor fingerprint. This work demonstrates for the first time that HLA influences production of specific odor.

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Document Details

Document Type
Technical Report
Publication Date
Nov 25, 2007
Accession Number
ADA482999

Entities

People

  • Cristina E Davis

Organizations

  • University of California

Tags

Communities of Interest

  • C4I
  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Amplitude
  • Cell Line
  • Cells
  • Culture Techniques
  • Data Analysis
  • Engineering
  • Gas Chromatography
  • Mass Spectrometry
  • Medical Personnel
  • Organic Compounds
  • Recognition
  • Spectrometry
  • Standards
  • Statistical Analysis
  • Students
  • Volatile Organic Compounds

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Immunology
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech