Comparison of the Immune Response To Coxiella burnetii and Burkholderia mallei in Balb/C Mice: A Differential Response by Two Diverse Biological Agents

Abstract

We compared the immune response of BALB/c mice to two biological agents, Coxiella burnetii and Burkholderia mallei. Both C. burnetii and B. mallei cell preparations induced a proliferative and a mixed Th1- and Th2-like cytokine response in splenocytes from vaccinated mice. B. mallei cell preparations induced higher levels of IgG and IgM than did C. burnetii. The ratio of the subclasses IgG2a over IgG1 from C. burnetii vaccinated mice was higher than 1.0, while the ratio from B. mallei was lower than 1.0. The difference in the Th1-like response of the Ig subclasses may be part of the reason why vaccination with the C. burnetii can lead to a protective response, while vaccination with B. mallei does not.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA483048

Entities

People

  • David Deshazer
  • David M. Waag
  • Gary V. Bush
  • Kei Amemiya

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biological Factors
  • Biomedical Research
  • Cells
  • Cytokines
  • Diseases And Disorders
  • Gram-Negative Bacterial Infections
  • Health
  • Health Services
  • Immune System
  • Immunoglobulins
  • Infectious Diseases
  • Public Health
  • Q Fever
  • Rodents

Fields of Study

  • Biology
  • Medicine

Readers

  • Climatology
  • Immunology
  • Microbial Pathology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech