UV Exposure, Vitamin D, and Prostate Cancer Risk in African Americans
Abstract
Genes may play a strong role in prostate cancer etiology but epidemiological studies suggest that prostate cancer risk is largely determined by gene and environmental interactions. In order to explore the effects of UV exposure, serum Vitamin D, and skin color on prostate cancer risk in African American men. Ninety affected AA men with histologically diagnosed adenocarcinoma of the prostate; PSA of > 2.5 ng/ml and a positive DRE were recruited under the direction of Dr. Mireku-Boateng from the division of Urology at the Howard University Hospital and forty age and ethnicity matched controls have been recruited through the monthly free screenings program at the Howard University Cancer Center. For each prostate cancer patient and matched control we have collected information on personal and family history, and blood samples for candidate gene testing. In order to measure the intake of dietary Vitamin D each subject completed the standardized food frequency questionnaire and the serum circulating levels of 25-OH Vitamin D have been measured by Enzyme Immunoassay for all participants. To elucidate their exposure to UV from childhood until current the UV exposure questionnaire has been completed. In addition their constitutive skin color (M-index) measured has been done by using the dermaspectrophotometer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2007
- Accession Number
- ADA483179
Entities
People
- Yasmine Kanaan
Organizations
- Howard University