Molecular Mechanism of Nkx3.1 Deregulation and its Function in Murine Pten Prostate Cancer Model

Abstract

Both PTEN and Nkx3.1 play important role in prostate cancer control. Preliminary results from Pten prostate model indicated that reduced Nkx3.1 expression is correlated with Cre-mediated Pten deletion. The goal of this study is to investigate how these two proteins interplay in prostate cancer development. We demonstrate that restoration of Nkx3.1 into Pten null prostate epithelium can lead to increases cell apoptosis, decreased cell proliferation and prevention of tumor initiation. The anti-tumor effect of Nkx3.1 is correlated with stabilization p53, inhibition Akt activation and AR function. This novel finding was published in Cancer cell. We generated and characterize the primary cell lines from Pten prostate cancer model, which will facilitate us to study the molecular mechanism of hormone refractory prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2006
Accession Number
ADA483242

Entities

People

  • Jing Jiao

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Apoptosis
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosomes
  • Epithelium
  • Gene Expression
  • Genetic Engineering
  • Genetics
  • Health Services
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins

Fields of Study

  • Biology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).