The Development of Therapeutic and Diagnostic Countermeasures to WMD by the Advanced Medical Countermeasures Consortium

Abstract

Acute lung injury in rats following airway delivery of CEES is associated with loss of distal lung barrier function (resulting in alveolar flooring) and an intense inflammatory response, which is lung-damaging. These acute lung injury parameters are attenuated by neutrophil depletion or complement blockade. Injuring the redox balance in lung after exposure to CEES by administration into lung of liposomes containing antioxidant compounds is highly protective even when delivery of liposomes is delayed by at least 1 hr. CEES-induced lung injury is progressive, as manifested by development of interstitial fibrosis which seems to peak at three weeks. Whether STIMAL will attenuate development of lung fibrosis is currently unknown.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2007
Accession Number
ADA483310

Entities

People

  • Milton G. Smith
  • Peter A. Ward

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Lung Diseases
  • Medical Personnel
  • Organic Chemistry

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology