Investigation of Murine Models for Sleep, Wakefulness and Target Discovery
Abstract
Genetic inhibition of two genes, an orphan GPCR and a kinase, have been shown to produce changes in the behavior of mice that suggest the ability to promote sleep and to promote extended wakefulness. One of these is a well-known clock gene, but its effects on normal sleep-wake states had not been characterized. Pharmaceutical investigation of either of these genes appears to be very limited, but could be fruitful in developing compounds to modulate human wakefulness and sleep. The phenotype of a third gene, that had been seen to consistently affect circadian rhythm of activity in early breeding generations, was lost following additional breeding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2007
- Accession Number
- ADA483350
Entities
People
- Gui-lan Ye
- Katerina Savelieva
- Thomas Lanthorn